The mechanism involved inhibition of cell proliferation, induced cell cycle arrest, and apoptosis. MBE may also have antimicrobial activity against Helicobacter pylori.12, Chewing sugarless gum containing either MBE (0.17%) + xylitol or xylitol without MBE was shown to improve mutans streptococci levels and bleeding on probing significantly better than control. Common Name(s): "Hu-bak", Magnolia bark. CAS Number: 85085-47-8 EINECS/ELINCS No: 285-376-6 COSING REF No: 84188 Chem/IUPAC Name: Magnolia Grandiflora Bark Extract is the extract of the bark of the Magnolia grandiflora L., Magnoliaceae One small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms. Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. Most literature sources are from Japanese and Chinese foreign-language publications, and clinical studies on the efficacy of magnolia bark extract are limited. Both compounds also enhanced vitamin D3 and all-trans-retinoic acid induced HL-60 leukemic cell differentiation.31, Magnolol suppressed growth of cultured human U373 malignant glioblastoma cells by inhibiting DNA synthesis and activating apoptosis. Health Concerns of the Ingredient: Overall Hazard . Honokiol (C18H18O2), a biphenolic phytochemical, is one of the bioactive constituents of the bark and leaves of Magnolia plant species. Magnolol may stimulate corticosterone secretion or increase steroid medication concentrations. An animal study documented that honokiol and magnolol blocked calcium-dependent uterine oscillatory contractions in rat uterus.5. Magnolia bark also appears to have potent antibacterial and anti-inflammatory effects. Several strengths are available for Relora, a patented blend marketed as "a natural stress management supplement" that includes MBE. This information should not be used to decide whether or not to take this product. A human skin irritation test in 30 healthy patients demonstrated no adverse effects from topical application of the phenolic compounds. PhytoDefense CLR™ by CLR Berlin acts as an anti-inflammatory and anti-redness agent. Magnolia bark is a natural remedy sourced from the magnolia tree (Magnolia officinalis) that has been used for centuries in traditional Chinese medicine (TCM).It contains a compound called honokiol that mimics the function of estrogen in the body. The bark (or the extract) is quite soluble in water. Magnolia Grandiflora Price - Select 2020 high quality Magnolia Grandiflora Price products in best price from certified Chinese Magnolia Bark Extract Powder manufacturers, Magnolia Denudata suppliers, wholesalers and factory on Made-in-China.com Magnolia bark extract is one of the most potent anti-wrinkle ingredients tested so far at NIVEA. Other ingredients in the smoothie can help mask the bark’s taste in case it doesn’t appeal to you. Drug-herb interactions are documented, and caution is advisable in patients self-medicating with MBE. Magnolia bark (Magnolia officinalis) is a traditional Chinese medicine used since 100 A.D. to support the body and nurture wellbeing and to treat a plethora of ailments. MAGNOLIA GRANDIFLORA BARK EXTRACT. Water or alcohol extracts its virtues. MBE and honokiol may interact with benzodiazepines. Magnolol also attenuated upregulation of renal transforming growth factor beta 1, which plays a key role in the pathogenesis of diabetic nephropathy, and reduced expression of extracellular matrix protein as type IV collagen.40 In mature adipocytes, magnolol improved insulin sensitivity by increasing basal and insulin stimulated glucose uptake through peroxisome proliferator-activated receptors.41 KIOM-4, a plant extract obtained from M. officinalis, protected pancreatic beta cells against streptozotocin-induced oxidative damage.42 KIOM-4 induced a rate-limiting enzyme through the extracellular regulated kinase pathway, which resulted in cytoprotection against diabetic conditions and increased insulin release from the pancreas. MBE may cause excess sleepiness, vertigo, and dizziness in patients taking muscle relaxants. Medicinal uses Magnolia bark has been used to treat menstrual cramps, abdominal pain, abdominal bloating and gas, nausea, and indigestion. We comply with the HONcode standard for trustworthy health information -. Additive adverse reactions with antiplatelet medications may occur in patients also self-medicating with magnolol. EINECs: 285-376-6. 2011. Avoid use if hypersensitivity exists for any of the components in MBE. Chemical Composition.—The various species of Magnolia probably have analogous composition. The extract is obtained from the bark of the Magnolia officinalis plant and it contains high amounts of organic compounds magnolol and honokiol, which are said to be up to 1000 times more potent in antioxidants than vitamin E. The anti-inflammatory properties of magnolol and honokiol also effectively help to fight and inhibit the activation of NF-KB, a key facilitator in the aging and chronic inflammation processes. It has been used in traditional Chinese medicine called houpu or hou po for hundreds of years, and it is recognized worldwide for its medicinal properties. The study summarized above was the only study included that evaluated magnolia bark extract.73. Magnolia is a plant genus in the family of Magnoliaceae. You also agree that the data may also be transferred to third countries outside the European Economic Area without an adequate level of data protection (esp. Modern science is now exposing the health benefits of magnolia bark supplements. in the bark of the Houpu magnolia or in M. grandiflora. Magnolia bark extract is a fluid alcohol extracted from the bark of a magnolia plant and frequently administered as an herbal medicine. Honokiol Promotes relaxation and sense of calm, while magnolol has anti-inflammatory and antineoplastic effects. Magnolia bark extract has been used for centuries for its anti-inflammatory purposes in Traditional Chinese Medicine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Cells and cell culture: THP-1 cells b were cultured in a medium containing 10% heat-inactivated fetal bovine serum, 100 U/mL of penicillin and Participants were instructed to chew 1 or 2 pieces of gum for 5 minutes 3 times daily for 30 days (5 pieces/day); this regimen delivered 11.9 mg/day of magnolol and 2.2 g/day of honokiol. The extract also has anti-oxidant and anti-bacterial properties, which helps to neutralise free radicals and decelerate the aging process. Developmental & reproductive toxicity . bark extract skin cellulite magnolia bark magnolia Prior art date 2011-11-02 Legal status (The legal status is an assumption and is not a legal conclusion. It is a bioactive compound found. In vitro and animal studies document potential efficacy as an antibacterial, anti-inflammatory, and anticancer agent, as well as for use with Alzheimer disease, depression, diabetes, and menopause. Magnolia, from these three species, was formerly official. Numerous documented medicinal properties are associated with 2 major phenolic constituents, magnolol and honokiol, from the stem bark of M. officinalis Rehd. See all the important information about this ingredient. However, with age, the immune system becomes less effective and inflammatory activity increases. Magnolia Grandiflora Bark Extract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This is only a brief summary of general information about this product. Dr. Low Dog noted that an earlier study from Italy found that magnolia bark extract combined with magnesium improved sleep, mood, depression and anxiety in menopausal women. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Normally, the body can handle free radicals, but if antioxidants are unavailable, or if too many free radicals have been produced they can damage our cells. Caries Res. Honokiol also enhanced the proapoptotic activity of lapatinib or rapamycin in her-2 over-expressed or low-expressed breast cancer models.34, Honokiol-hydrogel reduced the number of pleural tumor foci and prolonged survival time in malignant pleural effusion–bearing mice when compared with controls.
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